Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains.
Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.
WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.
Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein.
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.
TEAD mediates YAP-dependent gene induction and growth control.
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).
Structural insights into the YAP and TEAD complex.
Structural and functional analysis of the YAP-binding domain of human TEAD2.
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling.
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
Angiomotin-like proteins associate with and negatively regulate YAP1.
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
Yap1 acts downstream of α-catenin to control epidermal proliferation.
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
A directed protein interaction network for investigating intracellular signal transduction.
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling.
PTPN14 interacts with and negatively regulates the oncogenic function of YAP.
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.
PTPN14 is required for the density-dependent control of YAP1.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover.
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.
Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
A gp130-Src-YAP module links inflammation to epithelial regeneration.
AMPK modulates Hippo pathway activity to regulate energy homeostasis.
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Aerobic glycolysis tunes YAP/TAZ transcriptional activity.
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.
Architecture of the human interactome defines protein communities and disease networks.
Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.
Downregulation of YAP inhibits proliferation and induces apoptosis in Eca-109 cells.
Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ.
Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.
Proteome-wide analysis of phospho-regulated PDZ domain interactions.
Identification of genes involved in the regulation of TERT in hepatocellular carcinoma.
Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
Human transcription factor protein interaction networks.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.
Quantitative fragmentomics allow affinity mapping of interactomes.
A central chaperone-like role for 14-3-3 proteins in human cells.
YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis.
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis.
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.
Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands.
Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.
Translocation of ERBB4s80:YAP1 complex to the nucleus
Phosphorylation of YAP by LATS2
Phosphorylation of YAP by LATS1
YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1
Translocation of YAP1 to the nucleus
Translocation of YAP1:ZO-2 (TJP2) to the nucleus
RUNX3 binds TEADs and YAP1
TEADs:YAP1 binds CTGF gene
The complex of RUNX1 and YAP1 binds the ITCH gene promoter
EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm
p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1
PP2A dephosphorylates serine-127 of YAP1
YAP1/TAZ binding to CD274 gene
Premetazoan origin of the hippo signaling pathway.
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Capsaspora Yorkie and Sd/TEAD together activate a Hippo-responsive reporter in fly cells.
"co-expression of Co-Sd and Co-Yki stimulated the transcription of the HRE-luciferase reporter in Drosophila S2R+ cells"
Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis.
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The Capsaspora Yorkie ortholog regulates cortical cytoskeleton but not proliferation.
"we demonstrate that coYki regulates cytoskeletal dynamics at the cell cortex but is dispensable for the proliferation of Capsaspora cells"
The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.
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Hyperactive coYki phenotypes require its TEAD-interaction residue, implying transcriptional activity.
"This result indicates that these phenotypes are mediated by the transcriptional activity of coYki."
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
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The ancestral Hippo pathway function was cytoskeletal regulation, not proliferation.
"We describe new evidence indicating that the ancestral function of this pathway was not regulation of proliferation, but of cytoskeletal dynamics, and that this pathway function predated the emergence of animals"