PPP1R15A (GADD34) review notes

Literature search (no deep-research provider available)

Sources checked: UniProt O75807 (curated FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTRAMEM/REGION features);
all 16 GOA-cited PMIDs cached via just fetch-gene-pmids. Context only: integrated stress response module
(gadd34_pp1_regulator annoton: GO:0019888, GO:0036496, cytosol) (module proposed in ai4curation/ai-gene-review#5904).

Key findings

• Holophosphatase: PMID:11381086
• Substrate redirection: PMID:11564868
• Scaffold: PMID:26095357
• ER membrane: PMID:21518769
• Influenza restriction: PMID:41747053 (abstract only)

Source defect found

DisProt IPI rows from PMID:34847777 (GO:0000164, GO:0071074) list UniProtKB:Q9BY44 = EIF2A (eIF-2A) as WITH/FROM;
the paper's substrate is Ser51-phosphorylated eIF2alpha = EIF2S1 (P05198). Recorded as WRONG_WITH_FROM / SYMBOL_COLLISION.
The same defect affects PPP1R15B rows (PMID:34847777, PMID:38159565).

Decisions

• molecular adaptor activity -> enzyme-substrate adaptor activity (GO:0140767).
• protein phosphatase activator activity -> parent regulator activity (GADD34 inhibits PP1 toward other substrates).
• regulation of translational initiation (in response to stress) -> GO:0036496 (by eIF2 alpha dephosphorylation).
• Golgi apparatus IDA left UNDECIDED (abstract silent; no UniProt Golgi location).