Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy.
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The original human fibroblast study linked FOXRED1 loss to complex I deficiency and rescued the defect by re-expression; its complex-I-specific framing describes that study, while later myoblast experiments found a contextual complex II effect.
"Silencing of FOXRED1 in human fibroblasts resulted in reduced complex I"
Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I.
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FOXRED1 is required for the mid-late stages of complex I assembly; FOXRED1-null cells retain only ~10% complex I and cannot grow on galactose, a late ~815 kDa intermediate fails to mature and degrades to ~475 kDa, and FOXRED1 co-immunoprecipitates with complex I subunits.
"that FOXRED1 is a crucial component in the productive assembly of complex I and"
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
A Mutation in the Flavin Adenine Dinucleotide-Dependent Oxidoreductase FOXRED1 Results in Cell-Type-Specific Assembly Defects in Oxidative Phosphorylation Complexes I and II.
A structural model for FOXRED1, an FAD-dependent oxidoreductase necessary for NADH: Ubiquinone oxidoreductase (complex I) assembly.
RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis.