Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Function and evolution of a mosquito salivary protein family
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D7 short proteins bind serotonin, histamine and norepinephrine with high affinity
"four of these five short D7 proteins and the D7 long form bind serotonin with high affinity, as well as histamine and norepinephrine"
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Scavenging host amines antagonizes vasoconstriction and platelet aggregation
"Scavenging of host amines would antagonize their vasoconstrictor, platelet-aggregating, and pain-inducing properties"
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D7 family evolved similar function to tick and bug lipocalins
"counteracting biogenic amines is of strong adaptive value in the convergent evolution of arthropods to hematophagy"
Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
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D7r2 identified by mass spectrometry in female A. gambiae saliva
"A proteomic and immunoproteomic analysis of anopheles and Aedes saliva allowed for the identification of some antigens that were recognized by most of the exposed individuals"
A cluster of four D7-related genes is expressed in the salivary glands of the African malaria vector Anopheles gambiae
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D7r genes are expressed in adult female salivary glands
"Four genes expressed in the Anopheles gambiae adult female salivary glands and similar in sequence to the Aedes aegypti D7 gene were identified"
Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae
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D7-related genes were identified in A. gambiae salivary glands
"Fragments showing a high degree of similarity to D7 and apyrase, two salivary gland-specific genes previously found in Aedes aegypti, were identified"
UniProt entry for D7R2_ANOGA
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D7r2 modulates blood feeding by binding host mediators
"Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response"
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Binds serotonin, noradrenaline, histamine and adrenaline
"Binds serotonin, noradrenaline, histamine and adrenaline"
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Inhibits amine-induced smooth muscle contraction
"Inhibits histamine-, serotonin- and noradrenaline-induced smooth muscle contraction"
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Exhibits vasodilating activity
"Exhibits vasodilating activity"
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Expressed in female salivary gland
"Female salivary gland (PubMed:9990055)"
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Protein is secreted
"SUBCELLULAR LOCATION: Secreted"
Deep research review of D7r1 function and evolution (applies to D7 family)
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D7 proteins function as kratagonists that scavenge host signaling molecules
"D7 proteins are among the most abundant mosquito salivary proteins and function as kratagonists - high-affinity scavengers of host small-molecule inflammatory and hemostatic mediators"
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Short-form D7s bind biogenic amines
"Short-form D7s (including D7r1) predominantly bind biogenic amines (serotonin/5-HT, histamine, epinephrine/norepinephrine)"
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D7r proteins are secreted in saliva during feeding
"D7r1 is produced in adult female salivary glands and secreted in saliva at the skin interface during probing/feeding"