GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000116
Automatic Gene Ontology annotation based on Rhea mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10049825
Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.
PMID:10205054
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
PMID:10330164
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.
PMID:10362258
Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
PMID:10518217
A novel cofactor for p300 that regulates the p53 response.
PMID:10702269
cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription.
PMID:10722728
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
PMID:10733570
A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.
PMID:10821277
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
PMID:11029584
Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.
PMID:11073990
A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
PMID:11349124
A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.
PMID:11430825
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
PMID:11511361
A TPR motif cofactor contributes to p300 activity in the p53 response.
PMID:11581164
Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.
PMID:11909954
Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.
PMID:11940591
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.
PMID:11940655
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro.
PMID:12040021
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
PMID:12368347
Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300.
PMID:12408825
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.
PMID:12435739
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
PMID:12456660
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
PMID:12527917
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
PMID:12586840
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
PMID:12609999
The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:12743606
The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.
PMID:12750254
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
PMID:12929931
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.
PMID:1331501
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.
PMID:14645221
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
PMID:14716005
Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.
PMID:14752053
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:15075319
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.
PMID:15261140
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
PMID:15380363
Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity.
PMID:15448695
A new effector pathway links ATM kinase with the DNA damage response.
PMID:15509808
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
PMID:15542844
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
PMID:15588252
The Smad3 linker region contains a transcriptional activation domain.
PMID:15632193
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
PMID:15653507
Stat3 dimerization regulated by reversible acetylation of a single lysine residue.
PMID:15674325
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
PMID:15843474
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
PMID:15890677
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
PMID:15919823
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.
PMID:16135789
NF-kappaB RelA phosphorylation regulates RelA acetylation.
PMID:16219772
p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.
PMID:16257975
The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma.
PMID:16285960
STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.
PMID:16325578
A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.
PMID:16337145
Acetylation and alternative splicing regulate ZNF76-mediated transcription.
PMID:16574662
Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
PMID:16611888
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
PMID:16652169
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.
PMID:16687403
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.
PMID:16760386
Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity.
PMID:16864582
The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner.
PMID:16917507
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
PMID:17075044
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.
PMID:17150957
Functional architecture of atrophins.
PMID:17267393
Lysine propionylation and butyrylation are novel post-translational modifications in histones.
PMID:17382325
Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:17438265
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
PMID:17476304
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.
PMID:17641689
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.
PMID:17761950
Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.
PMID:17872950
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
PMID:17906639
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
PMID:18160048
Lyl1 interacts with CREB1 and alters expression of CREB1 target genes.
PMID:18268343
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
PMID:18391200
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
PMID:18451878
A transcription cofactor required for the heat-shock response.
PMID:18485870
Acetylation is indispensable for p53 activation.
PMID:18487222
Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.
PMID:18509338
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
PMID:18690848
NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.
PMID:18722353
Acetylation of Sirt2 by p300 attenuates its deacetylase activity.
PMID:18782771
The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.
PMID:19047049
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.
PMID:19064921
Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.
PMID:19071119
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.
PMID:19217391
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
PMID:19218448
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19680224
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
PMID:20018936
Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.
PMID:20019387
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.
PMID:20089040
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.
PMID:20228809
BRD7 is a candidate tumour suppressor gene required for p53 function.
PMID:20590529
Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.
PMID:20603618
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma.
PMID:20609350
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
PMID:20660480
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence.
PMID:20808282
A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.
PMID:20856196
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
PMID:20940255
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.
PMID:21030595
HDAC3 is negatively regulated by the nuclear protein DBC1.
PMID:21084751
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.
PMID:21108945
Acetyltransferase p300 regulates NBS1-mediated DNA damage response.
PMID:21131905
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
PMID:21471221
Novel nucleolar pathway connecting intracellular energy status with p53 activation.
PMID:21513714
The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22084251
Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.
PMID:22770219
Acetylation-dependent regulation of Skp2 function.
PMID:23010591
Structural features of human histone acetyltransferase p300 and its complex with p53.
PMID:23145062
Human ALKBH4 interacts with proteins associated with transcription.
PMID:23329847
Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
PMID:23415232
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
PMID:23441852
The corepressor activity of Alien is controlled by CREB-binding protein/p300.
PMID:23455922
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
PMID:23461825
Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression.
PMID:23746844
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
PMID:23811396
Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells.
PMID:23870121
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.
PMID:23934153
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
PMID:23962722
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.
PMID:23999430
Kruppel-like factor 15 is critical for vascular inflammation.
PMID:24120661
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
PMID:24229708
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
PMID:24413532
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.
PMID:24421387
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.
PMID:24529102
Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.
PMID:24852146
BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.
PMID:24939902
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.
PMID:25219498
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.
PMID:25245946
Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.
PMID:25314079
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
PMID:25514493
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.
PMID:25519132
An AUTS2-Polycomb complex activates gene expression in the CNS.
PMID:25593309
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
PMID:25651062
An acetyl-methyl switch drives a conformational change in p53.
PMID:25818647
Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.
PMID:26302407
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
PMID:26479788
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
PMID:26751287
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
PMID:26983400
SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300.
PMID:26990986
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.
PMID:27018634
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
PMID:27256286
A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.
PMID:28128295
RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
PMID:28262505
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
PMID:28386764
Roles of tau protein in health and disease.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:29775581
p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.
PMID:30193097
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.
PMID:30197302
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A.
PMID:31645732
Metabolic regulation of gene expression by histone lactylation.
PMID:32561715
Leucine regulates autophagy via acetylation of the mTORC1 component raptor.
PMID:32691935
LINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β-catenin signaling pathway.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:34545082
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid.
PMID:34637754
NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.
PMID:40240600
Histone H1 deamidation facilitates chromatin relaxation for DNA repair.
PMID:8684459
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
PMID:8945521
The transcriptional coactivators p300 and CBP are histone acetyltransferases.
PMID:9018065
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.
PMID:9194564
Synergistic activation of transcription by CBP and p53.
PMID:9194565
Binding and modulation of p53 by p300/CBP coactivators.
PMID:9811832
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.
PMID:9862959
Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
PMID:9881977
Direct suppression of Stat1 function during adenoviral infection.
PMID:9887100
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
Reactome:R-HSA-1028815
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
Reactome:R-HSA-1028817
CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
Reactome:R-HSA-1028819
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Reactome:R-HSA-1028820
Formation of VAF (virus-activated factor) complex
Reactome:R-HSA-1234167
Formation of HIF:CBP:p300 complex at promoters
Reactome:R-HSA-1912394
NICD1 in complex with RBPJ (CSL) recruits MAML
Reactome:R-HSA-2220957
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
Reactome:R-HSA-2220964
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
Reactome:R-HSA-2220971
CDK8 phosphorylates NICD1 PEST domain mutants
Reactome:R-HSA-3134883
Beta-catenin enhances association of IRF3 with CBP/p300
Reactome:R-HSA-3215152
TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
Reactome:R-HSA-3222093
BRD7 binds TP53 and EP300
Reactome:R-HSA-3322427
Beta-catenin recruits CBP/p300
Reactome:R-HSA-3371554
HSF1 acetylation at Lys80
Reactome:R-HSA-3371571
HSF1-dependent transactivation
Reactome:R-HSA-3662335
EP300 acetylates histone H2A, H2B, H3, H4
Reactome:R-HSA-3899291
SUMOylation of EP300 with SUMO1
Reactome:R-HSA-4088162
FOXM1 binds CDC25A promoter
Reactome:R-HSA-4396371
NOTCH1 Coactivator Complex binds MYC promoter
Reactome:R-HSA-4396379
NOTCH1 Coactivator Complex binds HES5 promoter
Reactome:R-HSA-4396392
NOTCH1 PEST domain mutants bind HES1 promoter
Reactome:R-HSA-4396393
NOTCH1 PEST domain mutants bind MYC promoter
Reactome:R-HSA-4396401
NOTCH1 PEST domain mutants bind HES5 promoter
Reactome:R-HSA-4396402
NOTCH1 PEST domain mutants bind promoters of HEY genes
Reactome:R-HSA-5250930
B-WICH recruits histone acetyltransferases
Reactome:R-HSA-5250938
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
Reactome:R-HSA-5621481
C-type lectin receptors (CLRs)
Reactome:R-HSA-5628871
BRD7 promotes EP300-mediated acetylation of TP53
Reactome:R-HSA-5660660
p300 acetylates RELA subunit
Reactome:R-HSA-5660666
CBP and p300 binds NF-kB complex
Reactome:R-HSA-5691381
MYSM1 deubiquitinates Histone H2A
Reactome:R-HSA-6804229
JMY, TTC5 and EP300 bind
Reactome:R-HSA-6804242
TP53 binds the complex of JMY, EP300 and TTC5
Reactome:R-HSA-6804379
PRMT5 binds TTC5
Reactome:R-HSA-6804383
PRMT5 methylates TP53
Reactome:R-HSA-6804758
Regulation of TP53 Activity through Acetylation
Reactome:R-HSA-6811479
ING2 recruits EP300 to TP53
Reactome:R-HSA-6811508
ING2-bound EP300 acetylates TP53
Reactome:R-HSA-8864307
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
Reactome:R-HSA-8878050
HIPK2 phosphorylates RUNX1 and EP300
Reactome:R-HSA-8878056
RUNX1:CBFB binds EP300
Reactome:R-HSA-8878220
RUNX3 binds the NOTCH1 coactivator complex
Reactome:R-HSA-8878237
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
Reactome:R-HSA-8935740
RUNX1 and GATA1 bind the promoter of the ITGA2B gene
Reactome:R-HSA-8936481
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
Reactome:R-HSA-8936616
RUNX1 and GATA1 bind the promoter of the GP1BA gene
Reactome:R-HSA-8936621
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
Reactome:R-HSA-8936979
RUNX1 and GATA1 bind the promoter of the THBS1 gene
Reactome:R-HSA-8937016
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
Reactome:R-HSA-8937037
RUNX1 and GATA1 bind the promoter of the MIR27A gene
Reactome:R-HSA-8937050
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
Reactome:R-HSA-8951951
RUNX3 binds EP300
Reactome:R-HSA-8951966
EP300 acetylates RUNX3
Reactome:R-HSA-8951977
Acetylated RUNX3 binds to BRD2
Reactome:R-HSA-8952058
CCND1 binds RUNX3 and displaces EP300
Reactome:R-HSA-9008271
CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter
Reactome:R-HSA-9008285
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3
Reactome:R-HSA-9009371
Binding of AP1 transcriptional activator complexes to CCND1 promoter
Reactome:R-HSA-9011981
EP300 is recruited to MYC and BCL2 genes
Reactome:R-HSA-9017835
NOTCH1 coactivator complex binds NOTCH3 gene
Reactome:R-HSA-9018499
ESR1:ESTG and EP300 are recruited to TFF3 promoter
Reactome:R-HSA-9021451
NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
Reactome:R-HSA-9023840
HATs and coactivators are recruited to the CTSD gene
Reactome:R-HSA-9023860
Histone acetyltransferases are recruited to the TFF1 gene
Reactome:R-HSA-9023884
NCOA1 recruits EP300 to TGFA promoter
Reactome:R-HSA-9029561
NCOA1 recruits EP300 to the ABCA1 promoter
Reactome:R-HSA-9038052
GREB1 binds ESR1:ESTG and co-activators
Reactome:R-HSA-9038163
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators
Reactome:R-HSA-933536
p-IRF7 dimer interacts with coactivator CBP/p300
Reactome:R-HSA-9613451
p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes
Reactome:R-HSA-9617064
SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene
Reactome:R-HSA-9701531
p-Y705,S727 STAT3 is acetylated
Reactome:R-HSA-9733207
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter
Reactome:R-HSA-9737710
SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter
Reactome:R-HSA-9759332
AcK-NFE2L2 binds the TXNRD1 promoter
Reactome:R-HSA-9760081
CREBBP, EP300 acetylates NFE2L2
Reactome:R-HSA-9760082
NFE2L2 binds CREBBP,EP300
Reactome:R-HSA-9760097
AcK-NFE2L2 and MAFK bind the GSTA1 gene
Reactome:R-HSA-9760099
AcK-NFE2L2 binds the GCLC gene
Reactome:R-HSA-9760103
AcK-NFE2L2 binds the GCLM gene
Reactome:R-HSA-9761812
AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
Reactome:R-HSA-9761815
AcK-NFE2L2 and ATF4 bind the SLC7A11 gene
Reactome:R-HSA-9761828
NFE2L2 binds the PGD gene
Reactome:R-HSA-9761836
p14ARF binds NFE2L2:CREBBP, EP300
Reactome:R-HSA-9796039
AcK-NFE2L2 binds the ABCF2 gene
Reactome:R-HSA-9796048
AcK-NFE2L2 binds the ABCG2 gene
Reactome:R-HSA-9796049
AcK-NFE2L2 binds the SOD3 gene
Reactome:R-HSA-9796050
AcK-NFE2L2 binds the KEAP1 gene
Reactome:R-HSA-9796051
AcK-NFE2L2 binds the AREG gene
Reactome:R-HSA-9796058
AcK-NFE2L2 binds the TXN gene
Reactome:R-HSA-9796059
AcK-NFE2L2 binds the BCL2 gene
Reactome:R-HSA-9796064
AcK-NFE2L2 binds the NOTCH1 gene
Reactome:R-HSA-9796065
AcK-NFE2L2 binds the ABCC3 gene
Reactome:R-HSA-9796066
AcK-NFE2L2 binds the CCL2 gene
Reactome:R-HSA-9796068
AcK-NFE2L2 binds the ATF4 gene
Reactome:R-HSA-9796077
AcK-NFE2L2 binds the ABCC1 gene
Reactome:R-HSA-9796082
AcK-NFE2L2 binds the EGF gene
Reactome:R-HSA-9796084
AcK-NFE2L2 binds the BCL2L1 gene
Reactome:R-HSA-9843120
Coactivators are recruited to liganded PPARG:RXRA heterodimer
Reactome:R-HSA-9909652
NFE2L2 binding to CD274 gene
Reactome:R-HSA-9926478
MITF-M binds CREBBP,EP300
Reactome:R-NUL-2064916
MAML recruits CDK8:CCNC to xNICD1
Reactome:R-NUL-2065178
CDK8 phosphorylates xNICD1
Reactome:R-NUL-4396363
mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
Reactome:R-NUL-9617710
EP300 binds SOH-C477-Foxo4
Reactome:R-NUL-9617742
TXN disrupts Foxo4 comples with EP300
Reactome:R-NUL-9617757
EP300 acetylates Foxo4
PMID:18273021
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
PMID:18644873
Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.
PMID:34798045
NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.
PMID:37172569
SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53.
PMID:26419803
Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
PMID:15616592
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.
PMID:18458156
Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation.
PMID:19229036
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
PMID:19822209
Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.
PMID:20955178
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
PMID:23752591
The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
PMID:24216764
p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation.
PMID:25200183
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.
PMID:27105113
Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.
PMID:35075301
BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16.
PMID:9742083
Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.