The exact HuRI pairs and clone limits are retained in the manual evidence page.
Species and construct limits are recorded in the manual evidence page. No additional natural product is inferred from experimental constructs or unexplained bands.
The conditional orthology proposal distinguishes a missing donor annotation from the independently supported experiment. The human record’s by-similarity functional statement is discussed explicitly; structural participation remains unresolved. The two incoming interaction judgments and single sequence product are retained.
MYO6 binding is supported directly in mouse and inferred for human GIPC3. The unresolved human mechanism is an MF knowledge gap rather than a small remaining detail of a settled core. Pairwise interactions do not establish simultaneous force transmission. Human apical localization remains untested. The dated donor annotation snapshot and corroborating PANTHER classification make the species boundary checkable.