Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry Q13510 (ASAH1_HUMAN), acid ceramidase
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Lysosomal ceramidase that hydrolyzes ceramide into sphingosine and free fatty acids at acidic pH; synthesized as a precursor autocatalytically cleaved into disulfide-linked alpha and beta subunits; requires saposin-D.
"Lysosomal ceramidase that hydrolyzes sphingolipid ceramides"
The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression.
Human acid ceramidase: processing, glycosylation, and lysosomal targeting.
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
The reverse activity of human acid ceramidase.
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase.
Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity.
Structural basis for the activation of acid ceramidase.
Purification, characterization, and biosynthesis of human acid ceramidase.
Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.
ASAH1 hydrolyzes ceramide
Exocytosis of tertiary granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
MITF-M-dependent ASAH1 expression