Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Intestinal epithelial cells secrete exosome-like vesicles.
The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation.
The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.
The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.
A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells.
Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Nuclear signalling by tumour-associated antigen EpCAM.
Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
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The gene-mapped human cDNA-fragment Y2H dataset contains CDH1–EPCAM (Table S2, mmc3.xlsx, NN1.0, row 3072); the read material does not establish pair-specific fragment boundaries or native mammalian validation.
Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.
EPCAM binds itself to form homotypic cell adhesion
FimH binds D-mannose moiety on host cell
Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctions.
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Human T84/Caco-2 experiments identify an extra-junctional lateral EPCAM–claudin pool and connect EPCAM abundance to claudin degradation and redistribution (Results Figures 1, 5–9).
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Human binding-impaired mutant rescue and claudin depletion connect the physical association to stabilization and junctional barrier effects, with residual mutant stabilization indicating that the mechanism is not exclusively established (Results Figure 10).
Claudin-7 regulates EpCAM-mediated functions in tumor progression.
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Rat EpCAM transmembrane mutations affect its association with claudin-7 in HEK and AS cells (Results Figures 1–2; Methods, pp. 296–298).
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EpCAM without associated claudin-7 increases aggregation/monolayer attachment in these models; the claudin-7-associated pool reduces those effects (Results Figure 3, pp. 288–292).
Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells.
EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion.
Spatial gene expression in the T-stage mouse metanephros.
Identification of EpCAM as the gene for congenital tufting enteropathy.
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.
EPCAM original-source access, experimental scope and annotation provenance