Annotation inferences using phylogenetic trees

PMID:14562095

Global analysis of protein localization in budding yeast.

Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae.

PMID:22570489

Yar1 protects the ribosomal protein Rps3 from aggregation.

PMID:24021814

Crystal structure of the yeast ribosomal protein rpS3 in complex with its chaperone Yar1.

The Rps3-Yar1 co-crystal structure supports a mechanism for Yar1 protecting Rps3 and facilitating nuclear import.

"Yar1 can protect rpS3 from aggregation while facilitating nuclear import"

PMID:8675027

A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation.

The original YAR1 characterization described a compact two-ankyrin-repeat protein whose repeats are similar to the Swi6 ankyrin repeats.

"The Yar1 ANK repeats are most similar to the conserved ANK repeats in the yeast cell cycle transcription factor, Swi6."

PMID:26112308

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.

PMID:37968396

The social and structural architecture of the yeast protein interactome.

file:yeast/YAR1/YAR1-goa.tsv

YAR1 GOA annotation snapshot

The current YAR1 GOA snapshot contains 22 rows, including five live IBA assertions from PANTHER source node PTN000917496 and a GO_REF:0000108 protein-folding inference from SGD's GO:0044183 row.

file:yeast/YAR1/YAR1-deep-research-falcon.md

Falcon deep research synthesis for YAR1

file:interpro/panther/PTHR24198/PTHR24198-metadata.yaml

PANTHER family PTHR24198 ankyrin repeat metadata

file:interpro/panther/PTHR24198/PTHR24198-paint.tsv

Current PAINT annotations for PTHR24198

PTN000917496 currently carries positive IBD assertions for GO:0005737, GO:0030907, GO:0000978, GO:0001228, GO:0000082, and GO:0045944. The sequence-specific DNA-binding and G1/S-transition assertions were added on 2026-02-24 and now propagate to Yar1, while the pinned GO:0033309 SBF-complex assertion is no longer present.

file:yeast/YAR1/YAR1-hypotheses/function-hypothesis-go-0001228/openscientist.md

OpenScientist hypothesis review of YAR1 GO:0001228

The report documents a small ankyrin architecture lacking an identified DNA-binding domain.

"The protein contains only two ankyrin repeats (residues 49–121) and no recognizable DNA-binding domain."
The report explicitly lacks a target transcription-complex interaction test.

"Whether YAR1 interacts with SWI4/SWI6/MBP1"

file:yeast/YAR1/YAR1-hypotheses/transcriptional-regulation-and-mbf-sbf-membership/openscientist.md

OpenScientist focused review of YAR1 transcription and MBF/SBF membership

The focused report found no primary experimental evidence that Yar1 directly regulates Pol II transcription or belongs to MBF or SBF.

"There is **no primary experimental evidence** that Yar1 promotes RNA Pol II transcription or is a subunit of the MBF"
The focused report found that curated SBF and MBF complex definitions contain Swi4/Swi6 and Mbp1/Swi6, respectively, but not Yar1.

"SBF (CPX-946) = Swi4 + Swi6; MBF (CPX-950) = Mbp1 + Swi6; **Yar1/P46683 absent from both**"
The focused report found that Yar1's curated IntAct interactome lacks Swi4, Swi6, and Mbp1.

"15 records; partners = Rps3, Ltv1 + Hsp70/Hsp40 chaperones (Ssa1/2, Ssb1, Sse1, Sis1, Ydj1, Hsp78/26, Erj5, Ess1, Sfm1); **no Swi4/Swi6/Mbp1**"

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links