Q9V4C9 is the selected 1140-residue dati isoform B, with six annotated C2H2 fingers at residues 439–682. PMID:25291190(https://pubmed.ncbi.nlm.nih.gov/25291190/) is cached with full text and establishes gene-specific nuclear localization, neuronal phenotypes and cholinergic-cell requirements. Its full-length rescue construct is identified as CG2052-PA; the selected B form retains the zinc-finger machinery, supporting broad functional transfer but not identical regulation at every target.
The original phmmer donor O43345 is human ZNF208, not ZNF384; its retained source record is a provenance check and is not treated as the experimentally characterized Dati homolog. The actual family relationship to Rotund/Squeeze and ZNF384 is stated in the primary Dati paper. PMID:11867614(https://pubmed.ncbi.nlm.nih.gov/11867614/) directly maps Nmp4 DNA-binding fingers and demonstrates context-dependent transcriptional activation. This supports broad cis-regulatory DNA binding as an inference, not target promoter identity or activation direction in Dati. QuickGO definitions for GO:0003700, GO:0000978 and GO:0001228 were inspected. The binding prediction is CNN, the activating activity UNC. Six original GOA rows are reviewed.
The selected frozen UniProt record is retained in dati-uniprot-source.json, with the complete original prediction metadata in dati-predictions-source.json. It maps the exact accession to this FlyBase gene; current sequence identity does not establish the historical predictor input. Gene-level experiments support conserved functions unless a relevant isoform difference is established. Falcon research was requested with perplexity-lite fallback alongside publication caching. Primary publications and sequence observations, rather than AI summaries or ARBA assertions, support the curated conclusions.
The completed Falcon report was read in full after the wrapper timed out; the original child returned successfully. The report confirms that the primary Dati evidence establishes a nuclear zinc-finger regulator and neuronal requirements, while direct targets and activation versus repression remain unresolved. Its newer thesis leads concern computational candidate targets and downstream RNAi phenotypes, not demonstrated Dati occupancy or activation; no new molecular target is asserted from those leads. The curated claims remain anchored to the independently read 2014 primary study (PMID:25291190) and characterized Nmp4 family DNA-binding experiments (PMID:11867614). Broad transcription regulation and cis-regulatory binding are CNN, because the exact gene was identified as a transcription factor before the prediction; the specific activating-function claim remains UNC.