GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10960098

Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis.

E. coli ubiB disruption eliminates CoQ and causes octaprenylphenol accumulation, establishing a conserved requirement for UbiB in the pathway without identifying UbiB as the hydroxylase.

PMID:27499294

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Characterized COQ8/Coq8 homologs lack canonical trans protein kinase activity and instead show ATPase activity and lipid CoQ-intermediate interactions that the authors infer are conserved across domains.

file:PSEPK/ubiB/ubiB-uniprot.txt

UniProt entry A0A140FWS4 for ubiB

The record assigns the UbiB/ABC1 family, a single C-terminal transmembrane segment, inner-membrane localization, and an inferred role in ubiquinone biosynthesis.

file:PSEPK/ubiB/ubiB-goa.tsv

QuickGO GOA annotations for ubiB

file:PSEPK/ubiB/ubiB-deep-research-openscientist.md

OpenScientist functional review of PSEPK ubiB

Family biochemistry, sequence architecture, and conserved pathway context support an ATP-dependent UbiB accessory role, while the report explicitly records the absence of direct PP_5013 experiments.