GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000033

Annotation inferences using phylogenetic trees

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

This reference identifies the original annotation inference method; each source row retains its exact evidence, qualifier and supporting entities.

PMID:10610180

The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.

Pallid mouse phenotypes include platelet storage-pool deficiency, pigment dilution and abnormal otolith formation; pallidin interacts with syntaxin 13.

PMID:12019270

BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules.

Human pallidin has soluble and peripheral membrane pools, self-associates and occurs in BLOC-1; pallidin-containing cytosol associates with F-actin.

PMID:12191018

Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.

Human pallidin is a component of a heterooligomer containing Muted; muted mouse cells have reduced pallidin.

PMID:15102850

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).

Endogenous complex biochemistry and interaction analysis identify the eight-subunit BLOC-1 assembly.

PMID:16189514

Towards a proteome-scale map of the human protein-protein interaction network.

A human interaction map supplies curated pallidin partner and self-interaction records.

PMID:17182842

BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.

Human PaHA restores pigmentation and Tyrp1 cargo routing in pallid mouse melanocytes.

PMID:19546860

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

Native brain BLOC-1 associates selectively with SNARE proteins; pallid mouse primary neurons have modest neurite-extension defects.

PMID:21998198

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.

Pallidin-containing BLOC-1 participates in neuronal cargo sorting and AP-3-associated complexes.

PMID:22203680

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).

Human pallidin, Cappuccino and BLOS1 form a stable subassembly within the reconstituted BLOC-1 octamer.

PMID:25416956

A proteome-scale map of the human interactome network.

A systematic human binary interactome supplies curated pallidin physical associations.

PMID:29892012

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

Human interaction perturbation experiments provide source-level physical-interaction context.

PMID:31515488

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A population-variant interaction study supplies curated pallidin interaction observations.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI supplies human binary-interaction evidence for source-listed pallidin partners.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

BioPlex maps physical associations in human cell lines.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

A multimodal human cell map supplies the pallidin–dysbindin association.

Reactome:R-HSA-429815

Formation Of Bloc-1 Complex

Reactome describes assembly of the eight-subunit BLOC-1 complex, including pallidin.

UniProt:Q9UL45

UniProtKB Q9UL45 (BL1S6_HUMAN): BLOC1S6

Human pallidin is a BLOC-1 subunit with three alternative products and recorded physical interactions.

"Component of the BLOC-1 complex"

PMID:28701731

BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus.

Pallid mouse hippocampi show altered metabolite pools and increased SNAT1; these changes do not establish a metabolic reaction performed by pallidin.

"28 metabolites that showed statistically significant changes"

PMID:17785837

Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase.

Pallid mouse inflammatory neutrophils release less elastase and fail to promote normal macrophage parasite killing.

"defective in the spontaneous release of NE"

PMID:22423091

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

Human pallidin knockdown alters BLOC-1 and COG-associated proteins and increases basal oxidant signal while reducing peroxiredoxins.

PMID:28317021

The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling.

Drosophila pallidin supports synaptic vesicle recycling under sustained activity, with activity-dependent endosomal changes.

PMID:28137951

Correction for BLOC-1 Is Required for Cargo-specific Sorting from Vacuolar Early Endosomes toward Lysosome-related Organelles.

The correction invalidates the original transferrin-FITC control and replaces it with validated transferrin recycling measurements.

PMID:22461475

Exome sequencing reveals a pallidin mutation in a Hermansky-Pudlak-like primary immunodeficiency syndrome.

A separate 2012 patient report describes impaired NK-cell degranulation and restoration of CD107a distribution after pallidin replacement.

PMID:21665000

A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9.

The 2011 pallidin case report is retracted and excluded from positive functional or disease evidence.

PMID:28475864

Retraction Notice to: A BLOC-1 Mutation Screen Reveals that PLDN Is Mutated in Hermansky-Pudlak Syndrome Type 9.

This notice formally retracts the 2011 pallidin case report PMID:21665000.