Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22.
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.
A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.
SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction.
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.
CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
PrPC directly interacts with proteins involved in signaling pathways.
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling.
'Srcasm: a novel Src activating and signaling molecule.
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.
Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence.
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
Bioinformatics and cellular signaling.
Prion protein interaction with the C-terminal SH3 domain of Grb2 studied using NMR and optical spectroscopy.
Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells.
Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma.
Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.
Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth.
LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.
Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein.
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells.
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
ShcA signalling is essential for tumour progression in mouse models of human breast cancer.
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Themis, a T cell-specific protein important for late thymocyte development.
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Themis2 is not required for B cell development, activation, and antibody responses.
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.
Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes.
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Identification of a ten-amino acid proline-rich SH3 binding site.
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.
Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
Recruitment of Gab2 to PM and FCERI by binding to Grb2
Phosphorylation of Gab2 by Syk/Fyn
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras
Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1
Active Flt3 dimer binds Grb2
Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated
Active Flt3:Grb2 binds Gab2
Active Flt3:Grb2:p-Y-Gab2 binds Ptpn11
Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1
p-Stat5 dissociates from activator:Stat5 complex
Activator phosphorylates Stat5
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1
Ntrk3 binds Grb2 through Shc1
UniProt record for Grb2 (Q60631)
Deep research report on Grb2 (falcon)