SERCA (DROME, P22700) review notes

Session 2026-10-28

• just fetch-gene DROME SERCA resolved P22700 (Swiss-Prot ATC1_DROME; FlyBase FBgn0263006;
  GeneID 49297). GOA has 37 rows. All 11 GOA PMIDs plus PMID:22952921 cached.
• No deep-research API keys; literature synthesis written by hand in SERCA-deep-research-manual.md.
• Full text available locally: PMID:22952921, 23434461, 24098595, 26205122, 28399403. Abstract only:
  PMID:15520268, 16899722, 19317464, 2148477, 23970561, 24807223, 33892078. PubMed MCP full-text
  for PMC6673814 (PMID:16899722) returned no body.

Key points

• Core function: P-type Ca2+-ATPase pumping cytosolic Ca2+ into the ER/SR lumen
  PMID:24807223.
• Only SERCA in the fly PMID:23434461.
• PMID:22952921 (photoreceptor lamina, Astorga et al. 2012): thapsigargin and sercaTS at 41 C reduce
  depolarization-induced FM dye labelling of photoreceptor boutons by about half/64%
  PMID:22952921.
  This is a downstream (store-filling) role; it does not justify a NEW process annotation on SERCA by
  the NEW bar (SERCA does not perform exocytosis), so it is used only as background.

Decisions worth flagging

• GO:0045202 synapse IEA (GO_REF:0000108) is inferred from the BP row neuromuscular synaptic
  transmission; a process phenotype cannot establish a location. REMOVE + source_defects (GO_CENTRAL).
• Generic membrane, endomembrane system, calcium ion transport, calcium ion transmembrane transport and the SR rows are MODIFIED to the specific terms the gene already carries
  (ER membrane, SR membrane, calcium ion transport from cytosol to ER).
• stabilization of membrane potential IGI (PMID:16899722): abstract does not mention membrane
  potential; full text not readable here. UNDECIDED.
• Notch-dependent developmental rows (stem cell differentiation, ISC homeostasis, follicle cell
  development) are indirect consequences of defective Notch receptor maturation; MARK_AS_OVER_ANNOTATED.
• adaptive thermogenesis IMP (PMID:28399403): the heat-producing experiments were on THADA mutants;
  SERCA itself performs the uncoupled ATP hydrolysis, so the involvement is plausible, but fly-specific
  SERCA thermogenesis was not directly measured. KEEP_AS_NON_CORE.