2026-11-07: Private preparation retained all 22 incoming contexts and the independently reproduced 22-row native forecast. No isoform-specific, negated or extended rows were present. One processed chain is preserved separately from alternative products. [UniProt:Q9HAV0]
One core section records the synthesis. Detailed decisions and source limits are in the review and source guide.
All source access and assay boundaries are recorded in the source guide. The evidence sidecar retains original qualifiers, partners, assignment dates and raw-to-forecast joins. Initial private Reactome wording was corrected against actual intermediate node names before final assembly; the reviewed client-location decisions were unchanged.
GNB4 provides the beta-subunit assembly and signaling interface in alpha–beta–gamma G-protein complexes, coupling GPCR activation to downstream responses. [PMID:11842130; PMID:23434117]
Official UniProt declares one 340-residue product and a processed chain spanning residues 2–340. This processing is not an alternative splice product. [UniProt:Q9HAV0]
Methods, Results and Figure 4 identify human clone AF300648.1 in COS7 cells. Wild type enhances IP3 signaling, but not maximal calcium response comparably. Separate HEK293T stability assays do not support mutant degradation. PMID:23434117
Human beta4/gamma2/alphaoA expression in rat neurons “resulted in heterotrimer formation.” PMID:11842130
The reviewed revision supersedes the initial action allocation: 5 ACCEPT, 12 KEEP_AS_NON_CORE, 4 REMOVE and 1 TOO_GENERAL across the same 22 incoming contexts; zero NEW. Direct cached snippets and linked original-source locators now accompany the decisions. The prior notes remain intact.