Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1.
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
Structure of the gene encoding human casein kinase II subunit beta.
KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.
Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling.
CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding.
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PRH/HHEX interacts with the CK2 beta subunit in vitro and in cells; CK2 phosphorylates the PRH homeodomain (S163, S177), inhibiting its DNA binding and transcriptional activity. CK2beta is important in CK2 assembly, stability and activity, can interact with substrates and modulators, and has roles independent of CK2 catalysis including negative regulation of cell proliferation.
Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling.
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CK2beta binds the cytoplasmic domain of ALK-1/ACVRL1 (CK2beta residues 181-199), enhancing ligand-stimulated Smad1/5/8 phosphorylation and ALK-1 reporter activity; CK2beta silencing reduces this signaling, and CK2beta with ALK-1 antagonizes endothelial cell migration and tubule formation.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.
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EBV EBNA1 binds CK2 via CK2beta, increasing association of CK2 with PML and PML phosphorylation, which triggers PML polyubiquitylation and degradation; CK2beta enhances catalytic activity/stability and can mediate interactions with CK2 substrates, redirecting CK2 toward specific substrates.
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Proteomic characterization of the human sperm nucleus.
A directed protein interaction network for investigating intracellular signal transduction.
p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence.
Toward an understanding of the protein interaction network of the human liver.
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.
Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.
Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.
An AUTS2-Polycomb complex activates gene expression in the CNS.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock.
Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta.
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.
A High-Density Map for Navigating the Human Polycomb Complexome.
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.
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CK2 (a tetramer of two catalytic and two regulatory beta subunits) phosphorylates HSJ1/DNAJB2 within its UIM2 (Ser250 dominant, Ser247 hierarchical), reducing HSJ1 binding to ubiquitylated clients and chaperone activity; CK2 inhibition enhances client binding, i.e. CK2 negatively regulates proteasomal degradation of HSJ1 clients. CK2 is highly pleiotropic and constitutively active and its major recognized function is counteracting apoptosis.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation.
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CK2beta mediates the interaction between ARKL1/ARK2N and c-Jun at the EBV Z promoter; silencing CK2beta (but not CK2alpha) phenocopies ARKL1 loss and promotes EBV reactivation, so CK2beta acts as an adaptor required for ARKL1-mediated repression of BZLF1/Zp and negative regulation of the viral life cycle. CSNK2B localizes to the nucleus and is active on chromatin.
Germline de novo variants in CSNK2B in Chinese patients with epilepsy.
CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders.
Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70-1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners.
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.
Multimodal cell maps as a foundation for structural and functional genomics.
UniProt entry P67870 (CSK2B_HUMAN)
CSNK2-mediated phosphorylation of DVL
CK2 phosphorylates condensin I subunits
Phosphorylation of L1 by CK-II
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
CK2:FACT phosphorylates TP53
Casein kinase II phosphorylates PTEN
Casein kinase II phosphorylates STARD10
FUNDC1 is phosphorylated by CK2
CK2 phosphorylates nascent P
M dimer is phosphorylated