Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500).

Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects.

ALX4 dysfunction disrupts craniofacial and epidermal development.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

A reference map of the human binary protein interactome.

Physical and genetic interactions between Alx4 and Cart1.

Alx4 binding to LEF-1 regulates N-CAM promoter activity.

ALX4 gain-of-function mutations in nonsyndromic craniosynostosis.

DNA-guided transcription factor cooperativity shapes face and limb mesenchyme.

Lineage-specific requirements of Alx4 function in craniofacial and hair development.

The ALX4 dimer structure provides insight into how disease alleles impact function.

UniProtKB reviewed entry ALX4_HUMAN

Subcellular - ALX4 - The Human Protein Atlas