Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Human galectin-3 is a novel chemoattractant for monocytes and macrophages.

Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling.

Galectin-9 induces maturation of human monocyte-derived dendritic cells.

Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse.

Defining the membrane proteome of NK cells.

Proteomics characterization of extracellular space components in the human aorta.

Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells.

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.

Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

Molecular cloning of a human macrophage lectin specific for galactose.

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway.

Modulation of CD6 function through interaction with Galectin-1 and -3.

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack.

A proteome-scale map of the human interactome network.

Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production.

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Architecture of the human interactome defines protein communities and disease networks.

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions.

Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization.

Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.

Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3.

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

A reference map of the human binary protein interactome.

MERIT, a cellular system coordinating lysosomal repair, removal and replacement.

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.

Multimodal cell maps as a foundation for structural and functional genomics.

Galectin-3 directs mitophagy in response to Parkin-/proteasome-dependent rupture of mitochondrial outer membrane.

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.

Expression of galectin-3 modulates T-cell growth and apoptosis.

Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.

Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma.

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

Exocytosis of secretory granule membrane proteins

Exocytosis of ficolin-rich granule membrane proteins

LGALS3 gene expression is stimulated by RUNX1 and RUNX2

Thermodynamic analysis of the binding of galactose and poly-N-acetyllactosamine derivatives to human galectin-3.

The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2).

Epsilon BP, a beta-galactoside-binding animal lectin, recognizes IgE receptor (Fc epsilon RI) and activates mast cells.

Shuttling of galectin-3 between the nucleus and cytoplasm.

Eosinophil-expressed galectin-3 regulates cell trafficking and migration.

Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia.