Gene Ontology annotation through association of InterPro records with GO terms

DOCK6 belongs to the DOCK family mapped to guanine-nucleotide exchange activity and small-GTPase signaling.

Annotation inferences using phylogenetic trees

The DOCK6 lineage inherits GEF and Rho-regulatory assertions at PTN000593987 and cytosol at PTN002762118.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

The curated DOCK6 subcellular record describes cytoplasmic and perinuclear pools.

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

Human DOCK6 has a supported cytosolic pool in immunofluorescence data.

PMID:32203420

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

Human DOCK6 associates with LRCH4 and has a cytosolic pool that LRCH coexpression can redistribute. The tested full-length protein and DHR2 fragment did not activate the three Rho-GTPase biosensors under the screen conditions.

Reactome:R-HSA-1011598

DOCKs bind to RhoGEFs

Full-length human DOCK6 is a cytosolic member of the modeled DOCK-GEF set acting on Rho GTPases.

PMID:17196961

Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.

Dock6 promotes nucleotide exchange on Rac1 and Cdc42 and supports neurite outgrowth in mouse N1E-115 cells.

PMID:21820096

Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome.

Biallelic human DOCK6 disruption is associated with Adams–Oliver syndrome and altered patient-fibroblast actin organization and morphology.

PMID:12432077

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK-family proteins provide an unconventional route to small-GTPase nucleotide exchange.

PMID:23462102

Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.

Akt and PP2A regulate mouse Dock6 activity during neuronal development.

PMID:27693507

Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.

Human cells with chronic DOCK6 loss can compensate for acute signaling defects through an ISG15/IQGAP1-associated response.

PMID:22634526

The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42.

Fly Zir participates in immune signaling through genetic interactions with Rac2 and Cdc42.

file:human/DOCK6/DOCK6-uniprot.txt

UniProt record for DOCK6 (Q96HP0)

The curated record identifies Rac1/CDC42 exchange and cytoplasmic/perinuclear localization.