Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation of UniProtKB entries based on the manual curation of subcellular locations
Gene Ontology annotation based on curation of immunofluorescence data
Interaction of human HSP22 (HSPB8) with other small heat shock proteins.
Some properties of human small heat shock protein Hsp22 (H11 or HspB8).
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Recombinant HSPB8 forms stable dimers, has negligible kinase/autophosphorylation activity and cannot phosphorylate casein or histone, but possesses ATP-independent chaperone (holdase) activity preventing heat-induced aggregation of alcohol dehydrogenase and rhodanese.
Towards a proteome-scale map of the human protein-protein interaction network.
HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.
HSPB7 is a SC35 speckle resident small heat shock protein.
Chaperone-assisted selective autophagy is essential for muscle maintenance.
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BAG3 coordinates Hsc70 (HSPA8) and the small HSP HSPB8 in chaperone-assisted selective autophagy (CASA), initiated by the ubiquitin ligase CHIP/STUB1 and the autophagy adaptor p62, to degrade damaged Z-disk components such as filamin; impaired CASA causes Z-disk disintegration and progressive muscle weakness.
Next-generation sequencing to generate interactome datasets.
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
Architecture of the human interactome defines protein communities and disease networks.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reactome annotation (nucleoplasm localization of HSPB8)
UniProt entry Q9UJY1 (HSPB8_HUMAN), Heat shock protein beta-8 (HSP22)
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Small heat shock protein involved in chaperone-assisted selective autophagy (CASA) with BAG3, HSPA8/HSC70 and STUB1/CHIP; temperature-dependent chaperone activity; interacts with HSPB1, DNAJB6, BAG3 and HSPA1A; cytoplasm and nucleus; muscle-enriched; dominant variants cause HMND2/CMT2L/MFM13.