Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.
Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC.
CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling.
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1.
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Proteomic analysis of SET-binding proteins.
Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.
Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2.
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.
KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2.
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions.
Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Casein kinase II-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation.
MDC1 collaborates with TopBP1 in DNA replication checkpoint control.
Next-generation sequencing to generate interactome datasets.
Proteomic characterization of the human sperm nucleus.
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.
p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence.
Toward an understanding of the protein interaction network of the human liver.
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.
A bead-based approach for large-scale identification of in vitro kinase substrates.
Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.
Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
The functional interactome landscape of the human histone deacetylase family.
The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator.
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
CK2α phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients.
A proteome-scale map of the human interactome network.
An AUTS2-Polycomb complex activates gene expression in the CNS.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.
A High-Density Map for Navigating the Human Polycomb Complexome.
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
Architecture of the human interactome defines protein communities and disease networks.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders.
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.
Multimodal cell maps as a foundation for structural and functional genomics.
CSNK2-mediated phosphorylation of DVL
CK2 phosphorylates condensin I subunits
Phosphorylation of L1 by CK-II
CK2:FACT phosphorylates TP53
Casein kinase II phosphorylates PTEN
Casein kinase II phosphorylates STARD10
FUNDC1 is phosphorylated by CK2
CK2 phosphorylates nascent P
M dimer is phosphorylated