Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Repression of LXRα by a novel member of additional sex comb-like family, ASXL3.
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ASXL3 represses ligand-dependent nuclear-receptor activity in the reported context.
"We determined that ASXL3 depletion augments the
ligand-induced transcriptional activities of LXRα and TRβ, which were repressed
by ASXL3 overexpression."
De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.
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A patient fibroblast ASXL3 truncating allele is associated with increased H2AK119 ubiquitination.
"Genome-wide H2AK119Ub1 level in ASXL3 +/fs fibroblasts was elevated 5-fold above control cells when normalized to histone H3"
BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.
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The BRD4-binding motif separates BRD4 association from BAP1 association.
"depletion of the 20 amino acids (ΔBBM) does not affect ASXL3/BAP1 interaction, but only completely abolished ASXL3/BRD4 interaction"
MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.
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ASXL PHD regions support MBD5/6-dependent complex assembly.
"MBD5 and MBD6) that bind to the C-terminal PHD fingers of the large
scaffold subunits ASXL1-3 and stabilize the BAP1 complex at the chromatin."