ZWF1 notes (P11412, YNL241C, MET19)

• G6PD EC 1.1.1.49 [UniProt:P11412 "Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-"]; oxidative PPP step 1/3.
• MET19 = G6PD; null requires organic sulfur PMID:2001672; AdoMet represses ZWF1 PMID:2001672.
• NADPH source, oxidant sensitivity PMID:2269430; decreased cytosolic NADPH/NADP+ [UniProt:P11412 "Decreases the cytosolic NADPH/NADP(+) ratio; this"].
• zwf1 suppresses gnd1 glucose-negative phenotype PMID:7045591.
• H2O2: pos allelic to ZWF1 PMID:7586028; adaptation defect beyond GR PMID:9480895.

Decisions: ACCEPT activity (all), oxidative PPP, PPP, NADPH regeneration, cytoplasm/cytosol; KEEP_AS_NON_CORE glucose metabolic process, response to H2O2, NADP binding; MODIFY GO:0016614 -> GO:0004345.

Autophagy (SGD description follow-up, 2026-11-01)

SGD calls Zwf1 a "negative regulator of nonselective autophagy, independent of Stb5p". The
source is Delorme-Axford et al. 2023, where zwf1 deletion modestly raised Pho8delta60 activity
under starvation PMID:37345792. The authors explain the effect through lower
NADPH pools, so it is an indirect metabolic effect of G6PD loss. It is recorded as peripheral and
not annotated.