Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Hepatitis C virus core protein interacts with cellular putative RNA helicase.
Hepatitis C virus core protein interacts with a human DEAD box protein DDX3.
Hepatitis C virus core protein binds to a DEAD box RNA helicase.
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.
Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity.
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.
DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication.
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.
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Selected original Methods, Figure 2C, Figures 4–5 and translation-reporter Results support export mRNP, initiation-factor and peripheral 40S associations.
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Identification of an antiapoptotic protein complex at death receptors.
Hepatitis C virus infection protein network.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.
DDX3 regulates cell growth through translational control of cyclin E1.
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication.
DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation.
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.
The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export.
The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes.
Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3.
Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Viral immune modulators perturb the human molecular network by common and unique strategies.
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.
Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.
Exploration of binary virus-host interactions using an infectious protein complementation assay.
Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation.
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
The DHX33 RNA Helicase Promotes mRNA Translation Initiation.
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP.
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription.
DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment.
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.
Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3.
DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways.
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity.
Functional coherence of the human Y chromosome.
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Correction: A motif unique to the human dead-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication.
DDX3X source evidence and annotation guide
DDX3X primary-source assay and correction notes