Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.
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LCAD-knockout mice show that long-chain acyl-CoA dehydrogenase is crucial for fatty acid oxidation, presenting with lipidosis, hypoglycemia, elevated serum free fatty acids and nonketotic dicarboxylic aciduria.
"lipidosis, hypoglycemia, elevated serum free fatty acids, and nonketotic dicarboxylic"
Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation.
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Mice with inherited fatty acid oxidation defects (including LCAD deficiency) show abnormal non-shivering thermogenesis and cold intolerance.
"Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation"
Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
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LCAD-deficient mice are compromised under cold and fasting stress, consistent with a requirement for long-chain fatty acid oxidation in stress responses.
"cold and fasting stresses, these mice"
Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice.
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LCAD-deficient mice develop hepatic steatosis upon fasting/cold exposure with altered PPAR-alpha-regulated gene induction, underlying the temperature-homeostasis and lipid/cholesterol regulatory phenotypes.
"LCAD-/-) develop hepatic steatosis upon"
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
A mitochondrial protein compendium elucidates complex I disease biology.
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.