Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:11980916

Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.

The purified mammalian COG complex includes GTC-90/COG5. Smaller COG5-containing material is also observed, with its origin unresolved. New knockout and localization experiments predominantly concern other COG subunits.

PMID:15047703

The binary interacting network of the conserved oligomeric Golgi tethering complex.

Human COG5 and COG7 associate and cooperatively incorporate COG6 into a reconstructed subcomplex. This supports an integral structural role.

PMID:19946888

Defining the membrane proteome of NK cells.

The study profiles the membrane fraction of the YTS NK-like cell line; the exact COG5 detection remains unverified.

PMID:27066481

COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits.

Human COG5 knockout disrupts subunit stability and Golgi ultrastructure. Replacement subunits localize to the Golgi and restore glycosylation phenotypes; pathway-level trafficking assays require their assay-specific limits.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Exact positive BioPlex records support COG5 association with COG4 and COG7 in HEK293T and HCT116 cells.

PMID:9792665

Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport.

GTC-90/COG5 is part of a transport-stimulating mammalian complex with cytosolic and Golgi-associated pools. Human splice cDNAs were characterized separately from the functional assay.

Reactome:R-HSA-6809006

Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-6809010

COPI vesicle uncoating

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-6809011

cis-Golgi t-SNAREs bind YKT6 on tethered vesicle

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-6811431

RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-6811433

The COG tethering complex interacts with numerous SNAREs at the Golgi membrane

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-6814682

Fusion of early-endosome derived vesicles at the TGN

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-8847544

The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-8847635

Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

Reactome:R-HSA-8849748

The COG complex binds RABs at the Golgi membrane

The curated event contains the Q9UP83-bearing COG complex at its modeled Golgi or trans-Golgi-network membrane location.

PMID:19690088

Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation.

A patient COG5 splice defect reduces protein abundance and delays fibroblast BFA-induced retrograde redistribution; wild-type cDNA rescues the defect. Serum glycoproteins show impaired sialylation.

PMID:23228021

COG5-CDG: expanding the clinical spectrum.

COG5-deficient patient fibroblasts have reduced COG5/COG7 abundance and delayed GalT-GFP redistribution from Golgi to ER. The clinical spectrum is broader than the first mild case.

PMID:33277529

COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage.

Two human COG5 variants perturb Golgi morphology in cell models and can activate PERK-associated stress. Separate retinal experiments manipulate PERK, not COG5 directly.

PMID:41824529

COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function.

COG5 associates with ATP7A in cells and affects its stability, copper balance and downstream respiratory phenotypes. ATP7A recycling/localization is a proposed mechanism rather than a directly resolved COG5 transport reaction.