Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.
C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Proteomics characterization of extracellular space components in the human aorta.
Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity.
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.
Protein profile of exosomes from trabecular meshwork cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix.
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)
Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans
XYLTs transfer Xyl to core protein
B3GAT dimers transfer GlcA to tetrasaccharide linker
B3GALT6 transfers Gal to the tetrasaccharide linker
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker
EXT1:EXT2 transfers GlcNAc to the heparan chain
EXT1:EXT2 transfers GlcA to heparan
NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
NDST1-4 N-deacetylates GlcNAc residues in heparan
HS-GAGs translocate to the lysosome for degradation
Some HSPGs are secreted to the plasma membrane
HS3ST1 sulfates GlcN at C3 in heparan sulfate
EXT1:EXT2 transfers GlcA to heparan
HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate
HS3ST2-6 sulfate GlcN at C3 in heparan sulfate
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer
HSPG2 (perlecan) binds alpha-dystroglycan
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
CR:atREs binds apoE and HSPG
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs
HSPG2 (perlecan) degradation by MMP14, MMP15
Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker
Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker
Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan
Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan
HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
Endorepellin binds alpha2beta1 integrin
Endorepellin binds KDR (VEGFR2)
Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
Amyloid fibrils have additional components
DGC complex binds AGRN and HSPG2
PXYLP1 dephosphorylates Xyl moiety
FAM20B phosphorylates Xyl moiety
EXTL3 dimer transfers GlcNAc to the GAG linker
Degradation of HSPG2 by Mmp13 and Ctss