PA3678 (mexL, Q9HXW2) review notes

PA3678 is the mexL locus, divergent from mexJK (PA3677-PA3676). UniProt carries no gene name.

Literature

MexL is a TetR-family repressor of mexJK PMID:12193619; a triclosan-resistant mutant carries a substitution in the MexL HTH.
Purified MexL is a tetramer and binds the 94-bp mexL-mexJ intergenic region PMID:15855505, regulating both mexL and mexJK PMID:15855505.

Search: PubMed metadata/abstracts for GOA-cited PMIDs (abstract-only caches).

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN004738546	GO:0006355 regulation of DNA-templated transcription	19	411 (33 taxa)	GO:0045892, IMP, PMID:12193619	SOUND	Abstract states mexL negatively regulates mexJK and the resistant mutant has a mexL HTH substitution; footprinting and fusions (PMID:15855505) confirm direct repression.	18 other seeds incl. AcrR, RutR, KstR, EthR	Yes
PTN004738546	GO:0000976 / GO:0003700 (not in worklist for this gene)	7 / 7	411	CollecTF IPI GO:0000976 / GO:0001217, PMID:15855505	SOUND	Not PseudoCAP; EMSA + footprinting.	AcrR, VC_1746, NfxB, others	Yes

Node-level verdict for PTN004738546 (all three IBDs stand on many experimentally characterised TetR regulators, no GO_CENTRAL defect) is recorded once in genes/PSEAE/nfxB/nfxB-notes.md.

No PseudoCAP defect for this gene.