Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:21905166

Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase.

A human disease-associated REP1 missense variant disrupts association with Rab geranylgeranyltransferase.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

The exact source reports a CHM–RABGGTA association in the human interactome screen.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

The literal source records retain CHM–RABGGTA association in two human-cell contexts.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

The official OpenCell dataset contains reciprocal CHM–RABGGTA affinity-MS associations, with an N-terminal endogenous CHM tag and unresolved prey protein groups.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

The U2OS AP–MS dataset contains the positive RABGGTA–CHM association.

PMID:7957092

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.

Isolated REP1–Rab complexes support membrane delivery, GDP-release inhibition and accessory prenylation work; Rab localization and downstream nucleotide exchange are not assigned as REP1 catalysis.

PMID:7981670

Cloning and characterization of the human choroideremia gene.

The complete human CHM coding region and patient rearrangement support gene identity and the disease context.

PMID:8380507

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.

Patient cells show deficient Rab geranylgeranyltransferase component-A function, connecting CHM to the accessory prenylation machinery.

Reactome:R-HSA-6801109

CHM binds RGGT

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8870465

RGGT binds the RAB-binding subunit

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8870466

RGGT:CHM binds RABs

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8870469

RGGT geranylgeranylates RAB proteins

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8875318

RAB3 GEFs exchange GTP for GDP on RAB3A

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8875320

RAB5 GEFs exchange GTP for GDP on RAB5

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876188

DENND4s exchange GTP for GDP on RAB10

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876190

RAB8 GEFs exchange GTP for GDP on RAB8

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876191

RAB9 GEFs exchange GTP for GDP on RAB9

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876193

RIC1-RGP1 exchanges GTP for GDP on RAB6

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876454

DENND3 exchanges GTP for GDP on RAB12

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876615

RAB13 GEFs exchange GTP for GDP on RAB13

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876616

DENND6A,B exchange GTP for GDP on RAB14

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8876837

RAB21 GEFs exchange GTP for GDP on RAB21

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877308

MADD exchanges GTP for GDP on RAB27

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877311

RAB31 GEFs exchange GTP for GDP on RAB31

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877451

MON1:CCZ1 exchanges GTP for GDP on RAB7

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877475

TRAPPC complexes exchange GTP for GDP on RAB1

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877612

DENND1s exchange GTP for GDP on RAB35

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877760

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877813

DENND5A,B exchange GTP for GDP on RAB39

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

Reactome:R-HSA-8877998

RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18

The event represents a cytosolic CHM-containing input or output entity; the retained annotation is compartmental.

PMID:18532927

Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.

Human REP1–RGGT binding supports Rab prenylation; GGPP stabilizes precomplex formation and promotes release of the prenylated Rab–REP product. The dominant in-vivo order and recycling role remain bounded interpretations.

file:human/CHM/CHM-source-evidence.json

CHM source-linked escort, interaction, localization, donor and ontology evidence