Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway.
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.
ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes.
Regulation and function of the interaction between the APC tumour suppressor protein and EB1.
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.
Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells.
Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.
alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.
Tcf4 can specifically recognize beta-catenin using alternative conformations.
Structure of a human Tcf4-beta-catenin complex.
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Beta-catenin binds cadherins and TCF/LEF.
"The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins"
Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.
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Beta-catenin is a dedicated coactivator of LEF/TCF.
"beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins"
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours.
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.
Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.
Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.
Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors.
Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).
The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta.
The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway.
Characterization of cadherin-24, a novel alternatively spliced type II cadherin.
A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
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The phosphodegron of beta-catenin is recognized by beta-TrCP1.
"The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB"
IpaC of Shigella binds to the C-terminal domain of beta-catenin.
WNT7a induces E-cadherin in lung cancer cells.
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.
Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion.
Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.
Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.
Epithelial-mesenchymal transition and its implications for fibrosis.
Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells.
Sox1 acts through multiple independent pathways to promote neurogenesis.
Wnt/beta-catenin and estrogen signaling converge in vivo.
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin.
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.
E-cadherin regulates the association between beta-catenin and actinin-4.
Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.
Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1.
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc.
TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.
Bcr interferes with beta-catenin-Tcf1 interaction.
Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.
Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin.
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.
The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.
Crystal structure of a beta-catenin/BCL9/Tcf4 complex.
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition.
Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression.
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands.
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids.
Vitamin D receptor is essential for normal keratinocyte stem cell function.
beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses.
E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription.
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
beta-Catenin is a Nek2 substrate involved in centrosome separation.
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells.
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.
VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability.
Sulindac suppresses beta-catenin expression in human cancer cells.
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer.
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.
The neurotransmitter dopamine modulates vascular permeability in the endothelium.
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Structural basis of beta-catenin recognition by Tax-interacting protein-1.
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.
Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract.
Molecular basis of actin reorganization promoted by binding of enterohaemorrhagic Escherichia coli EspB to alpha-catenin.
Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.
SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway.
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells.
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.
Kaiso is a bimodal modulator for Wnt/beta-catenin signaling.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro.
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein.
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
Telomerase modulates Wnt signalling by association with target gene chromatin.
Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling.
Lef-1 isoforms regulate different target genes and reduce cellular adhesion.
Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway.
The kinase TNIK is an essential activator of Wnt target genes.
GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells.
Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.
Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
An atlas of combinatorial transcriptional regulation in mouse and man.
Conductin/axin2 and Wnt signalling regulates centrosome cohesion.
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo.
The Hippo pathway regulates Wnt/beta-catenin signaling.
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
Receptor tyrosine phosphatase PTPγ is a regulator of spinal cord neurogenesis.
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling.
RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.
Yap1 acts downstream of α-catenin to control epidermal proliferation.
Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.
Targeting androgen receptor in estrogen receptor-negative breast cancer.
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis.
Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays.
The beta-catenin binding protein ICAT modulates androgen receptor activity.
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway.
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties.
Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling.
Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF.
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.
Radixin regulates cell migration and cell-cell adhesion through Rac1.
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin.
IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro.
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Identification of paxillin domains interacting with β-catenin.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions.
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.
β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.
Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Role of TAZ as mediator of Wnt signaling.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Physiological role of β-catenin/TCF signaling in neurons of the adult brain.
The protein interaction landscape of the human CMGC kinase group.
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.
Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis.
miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway.
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
The regulation and deregulation of Wnt signaling by PARK genes in health and disease.
Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.
MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab.
From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.
NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways.
Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin.
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.
In silico prediction of physical protein interactions and characterization of interactome orphans.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells.
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.
Loss of δ-catenin function in severe autism.
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Vitamin D receptor is a novel transcriptional regulator for Axin1.
Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer.
VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer.
Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.
Architecture of the human interactome defines protein communities and disease networks.
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a.
Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.
Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer.
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells.
FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer.
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway.
F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium.
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
β-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness.
A protein interaction landscape of breast cancer.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Quantitative fragmentomics allow affinity mapping of interactomes.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis.
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion.
Multimodal cell maps as a foundation for structural and functional genomics.
Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin.
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.
Phosphorylation of APC component of the destruction complex
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
Association of beta-catenin with the destruction complex
Phosphorylation of beta-catenin at Ser45 by CK1 alpha
Beta-catenin translocates to the nucleus
Beta-catenin is released from the destruction complex
Beta-catenin:TCF associates with BCL9 and PYGO
Caspase mediated cleavage of beta-catenin
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
Degradation of ubiquitinated beta catenin by the proteasome
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
Beta-catenin enhances association of IRF3 with CBP/p300
LRR FLII-interacting protein 1 associates with beta-catenin
Phosphorylation of beta-catenin at Ser552
Beta-catenin migrates to the nucleus
Beta-catenin displaces TLE:HDAC1 from TCF/LEF
Beta-catenin recruits SMARCA4
Beta-catenin recruits CDC73 and LEO1
Beta-catenin recruits CBP/p300
beta-catenin is replaced by repression complexes at the promoter
Recruitment of MLL2 methyltransferase complex
MLL2 complex trimethylates H3K4 at the MYC gene
APC promotes disassembly of beta-catenin transactivation complex
Beta-catenin recruits TRRAP/KAT5 HAT components
CDO binds promyogenic cadherins
XPO1 binds the beta-catenin:CBY complex
YWHAZ and XPO1 mediate the nuclear export of beta-catenin
CTNNBIP1 binds beta-catenin
TCF/LEF:CTNNB1 bind the AXIN2 gene
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene
NLK phosphorylates TCF/LEF
Nuclear translocation of p38 MAPK
Misspliced GSK3beta mutants stabilize beta-catenin levels
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression
Beta-catenin binds SOX proteins
TCF:Beta-catenin binds SOX proteins
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
SRC phosphorylates InlA-bound CDH1 and CTNNB1
CBLL1 binds SRC-phosphorylated CDH1 complex
CBLL1 ubiqutinates the InlA-bound CDH1 complex
TCF/LEF:CTNNB1 bind canonical WNT target promoters
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter
CDH11 associates with catenins
CTNNB1 dissociates from CDH11 upon ANGPTL4 binding
CDH1 translocates from ER to Golgi
CDH1 is proteolytically cleaved in Golgi
CDH1 translocates to the plasma membrane
CDH1 associates with CTNND1
CDH1:CTNNB1 complex binds CTNNA1
LEF1, CTNNB1 and MITF-M bind the MITF promoter
MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter
TCF/LEF:CTNNB1 binds the CCND1 gene
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter
CTNNB1 binding to CD274 gene
NS1 binds MMP9 and CTNNB1
CDH1-associated CTNNA1 binds VCL
CDH1:CTNNB1,JUP complex binds to ANK3
CDH1 forms homotypic trans-dimers
CDH1-associated CTNNA1 binds F-actin
CDH1 is phosphorylated on tyrosine residues
KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4
Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism.
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A beta-catenin-related armadillo protein acts both at junctions and in signalling in a non-animal.
"We have isolated a gene encoding a beta-catenin homologue, aardvark, which is a component of the junctional complex, and, independently, is required for cell signalling"
A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins.
Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex.
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Sponge beta-catenin retains the residues needed for E-cadherin binding.
"Oc_bcat has two lysine residues (homologous to positions K312 and K435 in mouse) required for the interaction of mouse β-catenin with E-cadherin"
Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica.
An ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation.
Gene family innovation, conservation and loss on the animal stem lineage.
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Beta-catenin is an animal-specific gene family.
"this set of genes includes seven from the Wnt pathway (including Frizzled, Dishevelled, TCF/LEF and β-catenin)"
New insights into the evolution of metazoan cadherins and catenins.
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ARM repeats are older than animals.
"the cadherin repeat domain and the armadillo repeat domain, predate metazoans"
Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium.
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Aardvark has cytoskeletal and signalling roles in Dictyostelium development.
"Aardvark (Aar) is a Dictyostelium beta-catenin homologue with both cytoskeletal and signal transduction roles during development"
Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution.
CTNNB1 beta-catenin family taxonomic census (UniProt/PANTHER)
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PANTHER PTHR45976 has 4921 metazoan and 2 non-metazoan (likely contaminant plant) UniProt entries, none in choanoflagellates, filastereans, ichthyosporeans or Dictyostelium; Aardvark Q54I71 is classified in PTHR22895.
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.
The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo.
The receptor PTPRU is a redox sensitive pseudophosphatase.
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.
Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.
Editorial Note: Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner.