Global alignment of cached UniProt sequences gives 498/521 identical paired residues (95.6%). Paired coverage is 96.7% of human P49419 (539 aa) and 100.0% of horse A0A9L0RRL6 (521 aa).
Reproduce from the repository root with uv run python genes/HORSE/ALDH7A1/ALDH7A1-bioinformatics/align.py (Biopython). The full alignment is in alignment.txt; sequence hashes and scoring parameters are in results.json.
This measures conservation between the identified records. It is not a reciprocal orthology analysis and does not itself validate a functional annotation. Interpret it alongside locus identifiers, domain architecture and primary literature. The sequences are current cached UniProt records, not independently recovered prediction-time inputs.
These mappings report sequence conservation only; they do not validate targeting, activity or annotation transfer.
| Human feature | Human positions | Paired horse positions | Identical / paired |
|---|---|---|---|
| TRANSIT | 1–26 | 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26 | 16/26 |
| ACT_SITE | 296–296 | 278 | 1/1 |
| ACT_SITE | 330–330 | 312 | 1/1 |
| BINDING | 192–192 | 174 | 1/1 |
| BINDING | 192–192 | 174 | 1/1 |
| BINDING | 194–194 | 176 | 1/1 |
| BINDING | 194–194 | 176 | 1/1 |
| BINDING | 218–218 | 200 | 1/1 |
| BINDING | 218–218 | 200 | 1/1 |
| BINDING | 259–259 | 241 | 1/1 |
| BINDING | 259–259 | 241 | 1/1 |
| BINDING | 275–275 | 257 | 1/1 |
| BINDING | 275–275 | 257 | 1/1 |
| BINDING | 296–296 | 278 | 1/1 |
| BINDING | 297–297 | 279 | 1/1 |
| BINDING | 297–297 | 279 | 1/1 |
| BINDING | 331–331 | 313 | 1/1 |
| BINDING | 427–427 | 409 | 1/1 |
| BINDING | 427–427 | 409 | 1/1 |
| BINDING | 489–489 | 471 | 1/1 |
| BINDING | 490–490 | 472 | 1/1 |