Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Anaplastic lymphoma kinase: signalling in development and disease.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.
Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling.
Structural basis of cytokine-mediated activation of ALK family receptors.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Physical and functional interactome atlas of human receptor tyrosine kinases.
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).
ALK binds ligand pleiotrophin (PTN)
PI3K synthesizes PIP3 downstream of ALK
ALK binds ligand midkine (MDK)
NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
ALK mutants bind type I TKIs
Active ALK dimer binds IRS1
Active ALK phosphorylates IRS1
Active ALK phosphorylates PLCG1
Active ALK phosphorylates SHC1
Ligand-independent dimerization of point mutants of ALK
Autophosphorylation of point mutants of ALK
ALK mutants phosphorylate SHC1
PTPRZ dephosphorylates ligand-bound ALK dimers
ASP-3026- resistant ALK mutants don't bind ASP-3026
alectinib resistant ALK mutants don't bind alectinib
ceritinib-resistant ALK mutants don't bind ceritinib
Liganded-ALK dimer binds type I ALK-binding TKIs
Active ALK phosphorylates JAK3
PTPN6 dephosphorylates JAK3
STAT3 is phosphorylated downstream of active ALK
PI3K synthesizes PIP3 downstream of ALK mutants
ALK mutants phosphorylate STAT3
lorlatinib-resistant ALK mutants don't bind lorlatinib
brigatinib-resistant ALK mutants don't bind brigatinib
crizotinib-resistant ALK mutants don't bind crizotinib
ALK mutants:p-3Y SHC binds GRB2
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants
p-7Y ALK dimer phosphorylates Frs2
Active ALK phosphorylates Src
Identification of ALK in Thinness.
Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.
Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish.
Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons.