Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity.
-
Tagged ARHGAP29 coimmunoprecipitates with Rasip1 under the reported conditions.
"As expected, Radil and ARHGAP29 co-immunoprecipitated with Rasip1"
A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.
-
PARG1 has GAP activity with preference for Rho over Rac and Cdc42 in vitro.
"The GAP domain is active on Rho, Rac, and Cdc42 in vitro but with a
clear preference for Rho"
RHOA GAPs stimulate RHOA GTPase activity
ARHGAP29 source and annotation review notes
PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector.
Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22.
Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.