NCU01245 is the conserved RPC4/C53 subunit of nuclear RNA polymerase III. It associates with the C37 subunit and supports promoter opening, transcription termination and polymerase recycling during synthesis of tRNAs and other polymerase III RNAs. Its role is structural and regulatory within the enzyme complex.
The exact current accession is Q1K6K5; NCU01245 is retained as the current locus identifier. No independently established formal gene-symbol replacement was found. Original claims are preserved in NCU01245-protnlm-source.json from the live API snapshot retrieved 2026-09-09T03:00:51.831347+00:00. The current sequence is not proven to be the prediction-time input, and placeholder API dates do not establish release or training membership.
The specific domain/family observation used is DR InterPro; IPR007811; RPC4.. Family membership and characterized relatives establish the inference; ARBA or AI-generated names are not independent functional evidence. PAINT is a curator-reviewed ancestral assertion, not donor-count evidence.
No unresolved GOA assertion remains at the reviewed level of specificity. Experimental observations on relatives are distinguished from target observations.
The actual Falcon report was inspected. It agrees with the RPC4/C53-C37 module and distinguishes RPC4 from the Rpb4-like C17 subunit. Its indirect termination and recycling model agrees with the primary reconstitution and crosslinking papers used here (PMID:16362040; PMID:19940126). Gene-specific Neurospora phenotypes and direct autonomous polymerase or nuclease catalysis are not inferred. References that foreground mutations in the partner C37 subunit are not used as direct RPC4 mutant experiments.