Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin.
Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human.
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The newly cloned rat and human pantophysin gene is broadly expressed.
"the synaptophysin-related gene is ubiquitously expressed in vitro and in vivo"
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Pantophysin was named to distinguish its ubiquitous distribution from specialized family members.
"To stress the ubiquity of expression in contrast to the restricted distribution of synaptophysin and synaptoporin, I propose to refer to the encoded polypeptide as pantophysin."
Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles.
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Pantophysin colocalizes with constitutive-secretory and endocytic vesicle markers in non-neuroendocrine cells.
"colocalizing with constitutive secretory and endocytotic vesicle markers in nonneuroendocrine cells"
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Most pantophysin immunoreactivity occurs on small vesicles under 100 nm in diameter.
"the majority of pantophysin reactivity is detected at vesicles with a diameter of < 100 nm"
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Pantophysin is a broad marker of small cytoplasmic transport vesicles.
"Pantophysin is therefore a broadly distributed marker of small cytoplasmic transport vesicles independent of their content."
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.
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The study detected an in vivo ALG3-SYPL1 interaction.
"provide experimental evidence for its in vivo interaction with the functionally linked proteins OSBP, OSBPL9 and LRP1, the SYPL1 protein and the transcription factor CREB3"
A reference map of the human binary protein interactome.
SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility.
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SYPL1 and VAMP3 govern formation and sequestration of sperm cytoplasmic-droplet saccules.
"This process is governed by a transmembrane protein SYPL1 and its interaction with VAMP3."
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Sypl1 loss prevents normal formation and accumulation of cytoplasmic-droplet saccular elements.
"Genetic ablation of SYPL1 in mice reveals that SYPL1 dictates the formation and accumulation of saccular elements in the forming cytoplasmic droplet."
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SYPL1 vesicles segregate key metabolic enzymes into the forming sperm cytoplasmic droplet.
"Derived from the Golgi, SYPL1 vesicles are critical for segregation of key metabolic enzymes within the forming cytoplasmic droplet of late spermatids and epididymal sperm, which are required for sperm development and male fertility."
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Mouse Sypl1 loss severely impairs sperm motility.
"KO epididymal sperm showed severely impaired motility"
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Cytoplasmic-droplet enrichment of SYPL1 and VAMP3 is conserved in human sperm.
"the enrichment of SYPL1 and VAMP3 is conserved, also appearing in the CDs of human spermatozoa"
UniProt entry for human SYPL1 (Q16563)
Manual literature synthesis for SYPL1