NPHP4 notes

Deep research: skipped. Falcon times out and perplexity-lite is unavailable in this environment. The review is based on cached publications, UniProt O75161 and PubMed.

Key findings

• In Chlamydomonas, NPHP4 is part of the transition-zone barrier PMID:25150219. It sits distally, near the membrane PMID:25150219.
• In C. elegans, NPHP-4 belongs to the NPHP module PMID:21422230.
• NPHP4 bridges NPHP1 and RPGRIP1L [PMID:17558407; PMID:21565611].
• It is needed for timely tight-junction formation PMID:19755384.
• It organizes the subapical actin network through INTU/DAAM1 PMID:26644512.
• It regulates Wnt signaling through JADE1 PMID:22654112. This is kept as non-core.

Decisions

• NAS rows citing PMID:12006559 (an NPHP1-only paper): structural molecule activity was removed; actin organization was kept as non-core on the basis of PMID:26644512; cell-cell adhesion was marked over-annotated.
• All protein-binding rows were removed as uninformative.
• No molecular function is set in core_functions.