CHA1 (YCL064C, P25379) notes

• Catabolic L-serine/threonine dehydratase, EC 4.3.1.17 and 4.3.1.19 [UniProt:P25379 "RecName: Full=Catabolic L-serine/threonine dehydratase;"].
• Discovery: PMID:7042346; prefers serine PMID:7042346; induced PMID:7042346.
• Location: mitochondrion (GFP PMID:14562095; proteomics PMID:16823961) [UniProt:P25379 "SUBCELLULAR LOCATION: Mitochondrion"]; mtDNA nucleoid association reported (PMID:15692048, abstract-only).
• Interaction with Rck1 kinase from HT screens (PMID:11805837, 17892321): protein binding -> REMOVE.

Curation observations

• RCA cytosol rows (SERDEG-PWY, THREOCAT2-PWY) -> REMOVE; YeastPathways default compartment.
• Not a member of BCAA biosynthesis: catabolic paralog of ILV1 (PTHR48078:SF2 vs ILV1 SF11). Cha1 threonine deaminase can produce 2-oxobutanoate but Ilv1 is the biosynthetic entry enzyme; limited cross-compensation PMID:7042346.