Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProt record for MONBRDRAFT_1233 (A9UVF9)
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The entry is a fragment, with non-terminal residues at both ends.
"Flags: Fragment;"
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PANTHER classifies A9UVF9 in the Warts subfamily of PTHR24356, with human LATS1/2.
"PANTHER; PTHR24356:SF418; SERINE_THREONINE-PROTEIN KINASE WARTS; 1."
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
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M. brevicollis is strictly unicellular.
"Although M. brevicollis is strictly unicellular, other choanoflagellates facultatively form colonies"
Premetazoan origin of the hippo signaling pathway.
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No Hpo homolog was found in M. brevicollis, probably through secondary loss.
"except for M. brevicollis and non-chytrid fungi, most likely due to secondary loses"
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Wts homologs are present across opisthokonts.
"Likewise, Wts homologues are present along all opisthokonts, except maybe for the ichthyosporeans, where the incompleteness of genome data makes it difficult to ensure its absence."
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
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The M. brevicollis Hippo gene is predicted to be truncated.
"Further, the M. brevicollis Hippo gene contains an insertion that is predicted to truncate the protein at the beginning of the kinase domain"
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M. brevicollis may have lost Hippo regulation of Yorkie.
"Thus M. brevicollis may be an example of an organism that encodes a Yorkie ortholog but has lost the capacity to be regulated by Hippo pathway signaling."
The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.
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The Capsaspora Hippo kinase cascade keeps the Yorkie homolog cytoplasmic.
"Together, these results show that the Capsaspora Hippo kinase cascade regulates coYki by cytoplasmic sequestration, indicating a premetazoan origin of this regulatory activity of the Hippo pathway."
Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis.
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Warts/LATS phosphorylates Yorkie/YAP/TAZ on HXRXXS motifs.
"In mammals and in Drosophila, YAP/TAZ/Yorkie is regulated by cytoplasmic sequestration in response to phosphorylation of HXRXXS motifs by the LATS/Warts kinases (Zheng and Pan, 2019)."
A fast and robust gene knockout method for <i>Salpingoeca rosetta</i> informs the genetics of choanoflagellate multicellular development
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S. rosetta warts knockout cells proliferate more slowly than wild type.
"On the other hand, hippopac1 and warts pac1 KO clones proliferated markedly slower"