Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:16030218

Characterization of a multigene-encoded sodium/hydrogen antiporter (sha) from Pseudomonas aeruginosa: its involvement in pathogenesis.

The PA1054-PA1059 cluster encodes a Na+/H+ antiporter; the abstract reports mutation of PA1054 only.

"We disrupted PA1054 (a shaA homologue gene) and determined its effect on Na+ tolerance during growth, Na+ efflux, and pathogenicity in mice."

PMID:20624916

Single site mutations in the hetero-oligomeric Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4 that affect Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation.

Mrp antiport requires the hetero-oligomeric complex of all Mrp subunits.

"Antiport activity requires hetero-oligomeric complexes of all six or seven hydrophobic Mrp proteins (MrpA-MrpG)."

PMID:29218041

Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.

In Gram-negative Mrp operons including P. aeruginosa, mrpA and mrpB are fused.

"in which it appears that the mrpA gene is fused with the mrpB gene encoding a fusion protein"

PMID:36241630

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.

MrpC lies in a hydrated region proposed to take part in Na+ transfer.

"the pronounced hydration in the vicinity of MrpC suggests a role in sodium transfer"

PMID:29754813

Structure of an Ancient Respiratory System.

Archaeal MBH contains an Mrp-like Na+-translocating module.

"The Na+-translocating unit, absent in complex I, resembles that found in the Mrp H+/Na+ antiporter"

file:PSEAE/PA1055/PA1055-uniprot.txt

UniProt entry Q9I4R9 (Q9I4R9_PSEAE)

file:PSEAE/PA1055/PA1055-bioinformatics/RESULTS.md

Composition of PAINT node PTN002160376 (PTHR34583) and its leaf IBAs