Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells.
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.
RASSF2 associates with and stabilizes the proapoptotic kinase MST2.
Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
The Hippo pathway regulates Wnt/beta-catenin signaling.
Network organization of the human autophagy system.
Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
Toward an understanding of the protein interaction network of the human liver.
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Architecture of the human interactome defines protein communities and disease networks.
SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
Phosphorylation of STK3 (MST2) and SAV1 by STK3
Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
Phosphorylation of MOB1A and B by p-STK3(MST2)/N
Cleavage of p-STK3 (p-MST2) by caspase 3
Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway.
Premetazoan origin of the hippo signaling pathway.
Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway.
The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.
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Loss of coHpo in Capsaspora increases nuclear coYki without changing proliferation.
"In adherent growth conditions, coWts-/- and coHpo-/- cells proliferated at similar rates as WT cells"
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
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Hippo kinase is the most ancient core Hippo component.
"among the core Hippo pathway components, the Hippo kinase appears most ancient, and is present in amoebozoans such as Dictyostelium discoideum and Acanthamoeba castellanii"
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Ancestral role is cytoskeletal; proliferation/tissue size control is a later co-option.
"The deep conservation of cytoskeletal regulation by the Hippo pathway indicates an ancestral role for the Hippo pathway in cytoskeletal regulation, implying a subsequent co-option of the pathway to constrain proliferation and tissue size in animals."
UniProt record for human STK3 (Q13188)