Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.
TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.
Towards a proteome-scale map of the human protein-protein interaction network.
Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.
Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.
Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.
Human Ccr4-Not complexes contain variable deadenylase subunits.
An atlas of combinatorial transcriptional regulation in mouse and man.
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy.
Architecture of the human interactome defines protein communities and disease networks.
Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
-
The neurodegeneration interaction screen supplies positive CNOT3 pairs with PECAM1, CALR, DLST, VCP and NEK7.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
CCR4-NOT complex deadenylates mRNA
BTG2 binds CCR4-NOT complex
NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
De novo variants in CNOT3 cause a variable neurodevelopmental disorder.
Structure and assembly of the NOT module of the human CCR4-NOT complex.
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT.
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes.
CNOT3 source provenance and assay-scope index