Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
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ISM1 binds cell-surface GRP78 with high affinity (Kd ~8.6 nM) and integrin alphaVbeta5 with low affinity
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ISM1-GRP78 complex is internalized via clathrin-mediated endocytosis
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ISM1 localizes to mitochondria and blocks ATP transport via ADP/ATP carriers
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Selective toxicity for cells with surface GRP78 expression
Advances in research of biological functions of Isthmin-1
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Comprehensive review of ISM1 structure, domains, and functions
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TSR1 and AMOP domains mediate distinct receptor interactions
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Context-dependent effects (soluble vs immobilized ISM1)
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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ISM1 identified as adipokine promoting glucose uptake
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Activates PI3K-Akt independent of insulin/IGF receptors
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Improves glucose tolerance and hepatic steatosis in mice
Isthmin-1 (ISM1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development
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ISM1 binds integrin alpha8beta1 in kidney mesenchyme
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Essential for ureteric bud branching and GDNF/RET signaling
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Ism1-/- mice show renal agenesis/dysplasia
Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by isthmin-1
ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis
ISM1 regulates NODAL signaling and asymmetric organ morphogenesis during development
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ISM1 is a specific inhibitor of Nodal signaling
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Binds directly to Nodal and ACVR1B via AMOP domain
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Essential for left-right patterning in embryos
Deep research synthesis on ISM1
Cyberian deep research on ISM1 function