Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Human chromosome 7: DNA sequence and biology.
The DNA sequence of human chromosome 7.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Evidence for a founder mutation causing DFNA5 hearing loss in East Asians.
Initial characterization of the human central proteome.
The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss.
The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways.
Pore-forming activity and structural autoinhibition of the gasdermin family.
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
A reference map of the human binary protein interactome.
Succination inactivates gasdermin D and blocks pyroptosis.
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.
Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME.
USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
SARS-CoV-2 3CL(pro) (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CL(pro).
Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.
Nonsyndromic hearing impairment is associated with a mutation in DFNA5.
GSDME expression mediated by TP53, TP63
GSDME (1-270) binds cardiolipin
GSDME variant does not bind PIPs
UniProtKB O60443 (GSDME_HUMAN) record
Independent GSDME source records, target paths and ontology comparisons