Gene Ontology annotation based on Enzyme Commission mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProtKB Q9Y673: human ALG5 curated catalytic function
UniProtKB A0A5F5PM72: selected horse ALG5 protein model
ALG5 human–horse sequence comparison
ALG5 re-review isoform identity and conservation of the missing segment
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A0A5F5PM72 pairs gaplessly with human isoform 2 (Q9Y673-2). The 30 residues it lacks (human 95-124) contain a strand and DDGS motif conserved across PTHR10859:SF91 orthologs from yeast to mouse. All other horse ALG5 UniProt entries contain the segment but are otherwise truncated, diverged or internally deleted.
A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.
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Human ALG5 cDNA partially complements the S. cerevisiae alg5 glycosylation defect (CPY hypoglycosylation), despite the ALG6-focused title.
"Expression of the humanALG5andALG6cDNA partially complemented the respective yeast mutations, as shown by the improved glycosylation of CPY"