Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Involvement of microRNA in AU-rich element-mediated mRNA instability.
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.
Identification of novel argonaute-associated proteins.
The role of PACT in the RNA silencing pathway.
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.
Identification of potential protein interactors of Lrrk2.
The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.
MicroRNA silencing through RISC recruitment of eIF6.
An mRNA m7G cap binding-like motif within human Ago2 represses translation.
RNA helicase A interacts with RISC in human cells and functions in RISC loading.
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system.
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
In vitro reconstitution of the human RISC-loading complex.
Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.
Structural insights into RNA processing by the human RISC-loading complex.
An integrated approach for experimental target identification of hypoxia-induced miR-210.
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.
Defining the membrane proteome of NK cells.
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.
ATP-dependent human RISC assembly pathways.
Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans.
Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2.
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Slicing-independent RISC activation requires the argonaute PAZ domain.
HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
Defining a new role of GW182 in maintaining miRNA stability.
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).
eIF4GI facilitates the MicroRNA-mediated gene silencing.
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells.
microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.
Structural features of Argonaute-GW182 protein interactions.
Involvement of telomerase reverse transcriptase in heterochromatin maintenance.
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Mammalian microtubule P-body dynamics are mediated by nesprin-1.
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs.
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Post-transcriptional gene silencing activity of human GIGYF2.
miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of angiogenesis defects related to inflammation.
Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G(1)/S phase transition.
Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.
Multivalent Recruitment of Human Argonaute by GW182.
Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.
MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro.
KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic identification of post-transcriptional regulatory modules.
MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
MIR200B/C microRNAs bind NOTCH1 mRNA
MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
p53 positively regulates transcription of MIR34 microRNAs
Dicer cleaves pre-miRNA to yield duplex miRNA
Duplex miRNA is loaded into Argonaute
Removal of siRNA passenger strand
Duplex siRNA is loaded into Argonaute
Removal of miRNA passenger strand
miR-26A microRNAs bind PTEN mRNA
Dicer cleaves double-stranded RNA to yield double-stranded siRNA
RISC binds inexactly matching target RNAs
Post-transcriptional silencing by small RNAs
Endonucleolytic RISC hydrolyzes target RNAs
miR-92b binds 3'UTR of NLK mRNA
Importin-8 binds AGO2:miRNA
AGO1,2:small RNA complexes interact with chromatin
Importin-8 imports AGO2:miRNA into the nucleus
TNRC6A:AGO2:miRNA is transported into the nucleus
FOXO3 regulates MIR34B,C expression
miR-302b binds RUNX1 mRNA
H19 is cleaved to produce miR-675
miR-17 microRNA binds PTEN mRNA
miR-19a microRNA binds PTEN mRNA
miR-22 microRNA binds PTEN mRNA
miR-25 microRNA binds PTEN mRNA
miR-93 microRNA binds PTEN mRNA
miR-106 microRNAs bind PTEN mRNA
miR-205 microRNA binds PTEN mRNA
miR-20 microRNAs bind PTEN mRNA
PTENP1 mRNA binds miR-19b RISC
PTENP1 mRNA binds miR-20 RISC
miR-19b microRNA binds PTEN mRNA
miR-17 microRNA binds VAPA mRNA
miR-17 microRNA binds CNOT6L mRNA
miR-19a microRNA binds VAPA mRNA
miR-19a microRNA binds CNOT6L mRNA
miR-19b microRNA binds CNOT6L mRNA
miR-20 microRNAs bind VAPA mRNA
miR-20 microRNAs bind CNOT6L mRNA
miR-106 microRNAs bind VAPA mRNA
miR-106a,(miR106b) microRNA binds CNOT6L mRNA
miR-26A and B bind to the 3'UTR of the GREB1 mRNA
miR-26A and B bind to the 3'UTR of the CHD11 mRNA
miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
C3PO hydrolyzes cleaved passenger strand
AGO2 cleaves passenger strand of duplex siRNA
miR-613 binds to the 3'UTR of the NR1H3 mRNA
miR-26 binds to the 3'UTR of the ARL4C mRNA
miR-26 binds to the 3'UTR of the ABCA1 mRNA
miR-33 binds to the 3'UTR of the ABCA1 mRNA
miR-144 binds to the 3'UTR of the ABCA1 mRNA
miR-200c-3p binds CDH11 mRNA
MIR27B microRNA binds 3'UTR of TGFBR3 mRNA
MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA
MIR23B microRNA binds 3'UTR of TGFBR3 mRNA
CD274 mRNA binds miR-93 RISC
CD274 mRNA binds miR-34 RISC
CD274 mRNA binds miR-429 RISC
CD274 mRNA binds miR-138-5p RISC
CD274 mRNA binds miR-340 RISC
CD274 mRNA binds miR-152 RISC
CD274 mRNA binds miR-140 RISC
CD274 mRNA binds miR-Let7-a1 RISC
CD274 mRNA binds miR-148a-3p RISC
CD274 mRNA binds miR-424 RISC
CD274 mRNA binds miR-142-5p RISC
CD274 mRNA binds miR-200B/C RISC
UniProt text export for AGO2
Falcon deep research report for AGO2
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.
Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.
Germline AGO2 mutations impair RNA interference and human neurological development.
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis.
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.
Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.