Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.
dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity.
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Smad3a with Smad4 activates the myf5 promoter and occupies its SMAD-binding elements in vivo; smad3b overexpression does not activate the promoter.
"Using a luciferase assay to detect myf5 promoter activity when smad2 , smad3a , smad3b , or smad4 mRNAs were overexpressed, we found that excessive smad2 and smad3a showed enhanced myf5 promoter activity but not excessive smad3b or smad4 mRNA."
Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signaling in the zebrafish embryo.
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Clock1a directly activates the smad3a promoter through an E-box; smad3a mRNA rescues clock1a morphant mesoderm and scl markers.
"Mechanistically, Clock1a activates the smad3a promoter via its E-box1 element (CAGATG)."
Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-β signaling.
Cloning and characterization of zebrafish smad2, smad3 and smad4.
Zebrafish Smad7 is regulated by Smad3 and BMP signals.
smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.
Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish.
A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development.
Evolution history of duplicated smad3 genes in teleost: insights from Japanese flounder, Paralichthys olivaceus.
Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
Interactions between the circadian clock and TGF-β signaling pathway in zebrafish.
Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration.
Novel SMAD3 variant identified in a patient with familial aortopathy modeled using a zebrafish embryo assay.
Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease.
smad3a/smad3b/human SMAD3/gar SMAD3 protein comparison and Bgee/ZFIN expression comparison