Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.
Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3.
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Architecture of the human interactome defines protein communities and disease networks.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Multimodal cell maps as a foundation for structural and functional genomics.
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative.
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.
The essential role of MEKK3 in TNF-induced NF-kappaB activation.
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.
Mekk3 is essential for early embryonic cardiovascular development.
The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.
PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.
14-3-3 proteins interact with specific MEK kinases.
MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway.
UniProt record for human MAP3K3 (Q99759)
Falcon deep research report for human MAP3K3