Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.

SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless.

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.

Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).

Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila.

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.

Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking.

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.