Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Gene Ontology annotation through association of InterPro records with GO terms
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein.
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model.
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase.
Cystatin B and SOD1: protein–protein interaction and possible relation to neurodegeneration.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
alpha-synuclein interacts with SOD1 and promotes its oligomerization.
Architecture of the human interactome defines protein communities and disease networks.
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.
Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.
Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants.
Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization.
Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS.
Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis.
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
Automatic transfer of experimentally verified manual GO annotation data to orthologs by Ensembl Compara
Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria.
Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1.
Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Gene Ontology annotation based on curation of immunofluorescence data
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
DJ-1 is a copper chaperone acting on SOD1 activation.
Expression of superoxide dismutase in whole lens prevents cataract formation.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.
Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.
Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Proteomic characterization of the human sperm nucleus.
SIRT5 desuccinylates and activates SOD1 to eliminate ROS.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells.
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.
Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport.
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Implication of copper zinc superoxide dismutase (SOD-1) in human placenta development.
Superoxide dismutase isoenzymes in the normal and diseased human cornea.
Differential localization of placental extracellular superoxide dismutase as pregnancy progresses.
Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.
Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome.
Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury.
Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor.
Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo.
Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.
Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1.
CuZn-superoxide dismutase, extracellular superoxide dismutase, and glutathione peroxidase in blood from individuals homozygous for Asp90Ala CuZu-superoxide dismutase mutation.
Mutation of SOD1 in ALS: a gain of a loss of function.
The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase.
Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activity.
Falcon deep research report for SOD1