GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11991638

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

CWC27 is present in native affinity-purified spliceosomes consisting largely of C complex, the basis for its catalytic step 2 spliceosome annotation.

PMID:20676357

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

CWC27 (SDCCAG-10) is a catalytically inactive cyclophilin with no detectable cyclosporin binding and no tetrapeptide isomerase activity.

PMID:29360106

Structure of the human activated spliceosome in three conformational states.

CWC27/NY-CO-10 is a component of the activated major (Bact) spliceosome and is released during the Bact-to-B* transition.

PMID:33509932

Structure of the activated human minor spliceosome.

CWC27 is a component of the activated human minor spliceosome that splices U12-type introns.

PMID:39068178

Molecular basis for the activation of human spliceosome.

CWC27 is identified within spliceosome activation intermediates spanning the pre-Bact to post-Bact states.

PMID:28285769

Mutations in the spliceosome component CWC27 cause retinal degeneration with or without additional developmental anomalies.

Biallelic loss-of-function variants in CWC27 cause autosomal-recessive retinitis pigmentosa with or without skeletal/developmental anomalies (RPSKA).

Reactome:R-HSA-9770131

Formation of the Spliceosomal B* complex

Reactome:R-HSA-9770145

Formation of the Spliceosomal Bact complex

Reactome:R-HSA-9921507

NS5 interacts with Spliceosome

file:human/CWC27/CWC27-deep-research-falcon.md

Falcon deep research report for CWC27

Synthesizes CWC27 as a catalytically inactive spliceosomal cyclophilin that acts as a structural/scaffold splicing factor; recruited to the activated Bact complex, released by the PRP2 helicase during the Bact-to-B* transition, and forming a CWC27-CWC22 heterodimer that serves as a landing platform for eIF4A3/EJC recruitment.